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It should be noted that both these therapies are primarily symptomatic; they do not directly address the production of the pathogenic factors.

Guillain Barre syndrome is an acute self-limited disease; therefore therapy is needed only for a limited period of time.

There is minimal information on other autoimmune rheumatic diseases.

There was early enthusiasm for PP/PE as a treatment of chronic rheumatic diseases.

Although PP/PE may remove circulating immunoglobulins and immune complexes, their local production may persist unabated.