Many Biz Talk Server operations are performed within the scope of a Microsoft Distributed Transaction Coordinator (MSDTC) transaction.
A clustered MSDTC resource must be available on the Windows Server cluster to provide transaction services for any clustered Biz Talk Server components or dependencies.
The third option is the Node And File Share Majority quorum configuration.
In node and file share majority, which is recommended for clusters that have an even number of nodes and that lack access to a witness disk, a witness file share is used as a tiebreaker node, and the failover cluster then runs as long as a majority of these nodes are online and available.
Biz Talk Server components or dependencies that can be configured as Windows Server cluster resources include the following: Windows Server 2003 only supports running MSDTC on cluster nodes as a clustered resource.